Highlights
- Analysis based on global warming, ocean acidification and salinity fluctuation.
- Multi-angle analysis of Sepia esculenta under temperature, pH and salinity stress.
- Different stress enhanced the immune defense and antioxidant defense of S.esculenta.
- The hub genes closely related to stress resistance were identified and screened out.
Abstract
The Sepia esculenta occupies a significant economic proportion in the squid family, and it is also the squid with the largest economic value in the northern sea area of China. With the occurrence of global warming, ocean acidification and ocean salinity fluctuations, it has caused serious negative effects on the development of the S. esculenta artificial breeding industry. Therefore, in the research, we employed weighted gene co-expression network analysis (WGCNA) to investigate the effects of three environmental factors, including salinity, temperature and pH, on the molecular mechanism of S. esculenta larvae, and proved the reliability of transcriptome results through physiological indicators. Enrichment analysis of each module indicated that environmental exposure markedly influenced immune function, oxidative stress responses, and other physiological processes in S. esculenta larvae. Our research elucidates the comprehensive response mechanism of S. esculenta under different environmental stresses, clarifies the significant molecular pathways essential for its growth and development.
Zhu X., Guo M., Ni L., Chang D., Wang W., Xu X., Liu X., Yang J. & Li Z., 2026. Response mechanism of Sepia esculenta larvae under global warming, ocean acidification and salinity fluctuation: Integrated biochemical and transcriptome profiling. Genomics: 111272. doi: 10.1016/j.ygeno.2026.111272. Article.
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