A new guide to running best practice experiments in ocean research was developed by the Scientific Committee on Oceanic Research (SCOR) Working Group 149. The Multiple Environmental Driver Design Lab for Experiments (MEDDLE) provides learning material and user-friendly experimental design tools to help scientists create accurate and statistically meaningful single and multi driver experiments. The MEDDLE simulator is a computer model that mimics some typical responses of marine organisms to multiple drivers. It allows users to run several virtual laboratory experiments by setting the combined levels of the drivers, choosing the number of replicates, and considering natural variability. The aim of this new tool is to provide guidance in supporting best practices for oceanic research.